Sequential neurohormonal response to felodipine in enalapril-treated heart failure: V-HeFT III
نویسندگان
چکیده
منابع مشابه
Neurohormonal Hypothesis in Heart Failure
A ccording to the neurohormonal model, heart failure is a syndrome that develops because an initial heart injury activates endogenous neurohormonal systems that exert a deleterious effect to the myocardium and on the circulation. This new model regards heart failure primarily as a neurohormonal disorder with main pathophysiologic abnormality the activation of various neurohormonal systems. Arte...
متن کاملRenal neurohormonal regulation in heart failure decompensation.
Decompensation in heart failure occurs when the heart fails to balance venous return with cardiac output, leading to fluid congestion and contributing to mortality. Decompensated heart failure can cause acute kidney injury (AKI), which further increases mortality. Heart failure activates signaling systems that are deleterious to kidneys such as renal sympathetic nerve activity (RSNA), renin-ang...
متن کاملCombined enalapril and felodipine extended release (ER) for systemic hypertension. Enalapril-Felodipine ER Factorial Study Group.
This multicenter, placebo-controlled, double-blind trial of factorial design evaluated the safety and efficacy of combination treatment with the angiotensin-converting enzyme inhibitor, enalapril, and the vascular selective calcium antagonist felodipine extended release (ER) in patients with essential hypertension. After a 4-week, single-blind placebo baseline period, 707 patients with sitting ...
متن کاملA Neurohormonal Modulator in Heart Failure?
Clinical Use of Digitalis Glycosides The potential benefit of digoxin therapy in heart failure patients is thought to be related to its positive inotropic effect that increases cardiac output and thereby decreases ventricular filling pressures.2 Although digoxin is undoubtedly an inotropic agent in tissue preparations,3 this effect, in contrast to other inotropic agents, is not consistently tra...
متن کاملEnalapril for severe heart failure in infancy.
Eight infants aged between 4 days and 12 weeks with severe heart failure that was refractory to optimal conventional treatment with diuretics were treated with enalapril. The starting dose was 0.1 mg/kg/day, increasing according to response to 0.12-0.43 mg/kg/day. One infant with severe myocarditis did not tolerate enalapril because of hypotension and later died of intractable heart failure. Si...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1996
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(96)80785-6